Warning: side-effects may include blue skin, among others

Feb 16, 2012 12:44 GMT  ·  By

As far back as the early 1800s, the Fugate family started producing children with blue skin. This mystery puzzled their neighbors and close ones, until a study finally revealed that genetic anomalies brought forth by generations of inbreeding and marriage within the family led to this condition.

As made obvious by this image, family members have a distinguishably blue skin. According to the Daily Mail, a weird combination of recessive genes is partially responsible for this discoloration.

The situation was perpetrated by interbreeding. The family lives in the Appalachian Mountains of North America, in eastern Kentucky, alongside the rivers of the aptly-named Troublesome Creek.

The condition that affects the family is called methemoglobinemia, and is characterized by the fact that blood loses parts of its ability to carry oxygen. As such, it becomes significantly darker than that of most people.