Scientists from the Huntsman Cancer Institute (HCI) at the University of Utah found a connection between some genes, which may lead to a healthier and longer life. Based on tests developed on some worms that have identical genetic designs as we do, researchers found that a gene associated with aging and another one linked to some forms of cancer are related. They have also observed – though not yet explained – that calorie consumption has a relative impact on the functionality of these genes.

 

The studied gene is called TOR, is related to cell growth regulation and affects cancer development. Susan Mango, one of the authors of the study, PhD, HCI investigator and professor at the Department of Oncological Sciences from the University of Utah explains: "In C. elegans, the tiny roundworm that our lab studies, as well as some other animals, a loss of TOR has been shown to slow aging. Our work with C. elegans reveals that TOR depends on a second gene called pha4/FoxA to control the aging process."

 

She further details on the fact that a low-calorie type of diet can slow the worms' aging process: "When there’s lots of food, TOR gets active, which decreases the action of pha4/FoxA down the line, and that in turn shortens the lifespan of C. elegans. When there’s little food, there’s little TOR and more pha4/FoxA, and that results in a longer lifespan."

 

There are many organisms that share the TOR gene and a gene pretty similar to the pha4/FoxA type, among which the most common are the studied roundworms, unicellular yeasts and mammals, including humans. For the mammals, FoxA has an active role in controlling cell metabolism and also has an impact on breast or prostate cancers. Further tests are needed in order to solidly establish whether a relationship between these factors can be used in order to control disease, metabolism and longevity in humans.