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Light Therapy Will Cure Nerve Damage

Tiny emitters near the spinal cord will release flashes of light

By Tudor Vieru, Science Editor

17th of November 2008, 14:52 GMT

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Damaged nerves mean that the flow of electricity coming or going to or from the brain no longer reaches its destination. This can happen during an accident, or it can be an inherited disability. Either way, the quality of life for people suffering from damaged nerves is significantly lower than that of average people, as broken nerves can often produce paralysis.
 

Modern-day science is currently trying to correct defects that may have seemed impossible to heal even a few years ago. Apparently, health experts decided that light was the best way to repair damaged nerves. At first, they used rats to test their theory. In the lab, scientists at the Massachusetts Institute of Technology (MIT), made neurons in Petri dishes think they were light receptors. This isn't nearly as easy to do as it may seem.
 

The team used viruses carrying the ChR2 gene, which codes a light-sensitive protein called channelrhodopsin-2. This made the neurons start secreting the protein, and thus they became able to respond to light stimuli. "The nerve cells think they are photoreceptors," Case Western Reserve University neuroscientist Jerry Silver said in 2005, when the first experiments began.
 

In the tests, mice were subjected to surgeries, and a part of their spinal cord was cut. The severed portion controlled a side of the diaphragm, so, naturally, the mice were left with breathing problems. Similar injuries are the lead cause of human deaths, following accidents.
 

After the surgeries, ChR2 was injected below the damaged area. After four days, the researchers operated on mice again, and shone visible light on the nerves. After three 5-minute long cycles of 1-second long pulses, "A bizarre seizure activity started," said Silver. After this episode, normal breathing settled in, with both sides of the diaphragm working fine, although they were not regulated by the brain.

 
This research could open up new paths of analysis for treating serious spinal cord damage, as the study proved that, if needed, secondary pathways can be activated to replace primary ones. In the future, small light-emitting devices could be installed next to spinal nerves, and thus eliminate the need for numerous surgeries on patients suffering from diaphragm paralysis.

TAGS:

light therapy | spinal damage | diaphragm | scientific study | medical breakthrough
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User opinions:


Comment #1 by: KAUSHAL RASTOGI on 19 Nov 2008, 12:48 GMT reply to this comment

DEAR SIR,MAM
i am 45 year old man before two years by the guilty of a doctor i damaged my nerves he inject an a harmful injection on my hip side then after 10 minutes i loss my sense to my legs from my brain then after a long teatment in VIHMANS HOSPITAL NEW-DELHI only i walk from my legs but beside this now i cannot fell any type of sense on my legs so i want to know your suggestions that my this promblem will be removed or cured.


Comment #2 by: tudor vieru on 19 Nov 2008, 14:01 GMT reply to this comment

dear mister Kaushal Rastogi

this type of treatment is still highly experimental, and it will most likely take a few more years before it is introduced in regular medical practices worldwide.

I imagine that now, since lab tests are complete, the researchers will move to human trials. But I'm not sure that test groups will be set in India as well.

Check back for updates on nerve damage therapies
Tudor Vieru


Comment #3 by: ivy on 04 Jan 2009, 03:50 GMT reply to this comment

sir/mam:
my husband was shot a year ago. and his lumbars and thurasics are damaged. and he cant walk again w/o walkers or crane. doctors told me that its bcoz his nerves are damaged. his bowels and urine are very irregular. can light therapy help him? or other surgery? procedure? pls. help we are from the philippines and i think we are being left behind here in terms of sciend and medication.. pls sir. thank you

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