HIV Research Breakthrough Brings Cure Closer

The article mistakenly states, "This could help molecular biologists create drugs that are targeted at this enzyme directly, a completely new approach to treating HIV." In fact integrase inhibitors already exist, one is FDA-approved and performing very well (ralegravir/Isentress). Scientists were able to come up with this compound despite not fully knowing it's mechanism of action. This new discovery showing the structure of the integrase enzyme may one day lead to better integrase inhibiting compounds, maybe some that the virus will not be able to evade through resistance.

cant you improve white blood cells to fight hiv then put them k in the human body

How long before the cure is released?

I hate to break it to you, but there's no guarantee that this will really lead to a cure, and even if it does, it could be decades before it's widely available. Such potential cures have always had to go through animal trials for years before they could be tested on any human subjects. The absolute fastest I can imagine a cure coming from this is ten years, and that's if it gets done in a big hurry.

how do you conduct animal trials on the human immunodeficiency virus?

@bobber You can humanise the immune systems of many animals in a lab environment. This is done quite regularly with mice. I has already been shown that zinc finger technology can be used to disable the ccr5-d32 gene in lymphocytes which thencan be infused back into the patient, providing profound 'control' over the virus.. doing away with the need for antiretroviral drugs. it is not a sterilising cure, but it is certainly a 'functional cure'.. this is the way the world will move if you ask me..

Don't u tink in five years there is going 2 b final cure

the cure is there pharamaceutical companys making to much money to reveal it

This is a good news and I hope the reseacher will be able to get CURE on HIV, and those who have not Faith stop to discarage people. Its time now for the CURE of HIV to be obtain.Goodluck and work day and nigth to makesure you got it soon.

I can see that we are 1 step to the aids cure,thanks to all the reseacher and scientist for the good work you are doing.keep it up wor harder than you normaly do we need this cure .

I consider this to be good news and I believe that there is a cure for HIV; first and foremost, one must have FAITH in the Creator who can and will remove all; Second, one must be obedient to his WILL to see that all things are remove in HIS time and not in thy own; doing what is required is mandatory, eating healthy, sleeping and feeding the soul on daily basis will heal anything while taking extra steps to enhance them;

I really liked your positive feedback...

what patronising comments to people like myself living with hiv i find your words offensive when you obviously dont live with this illness shame on you preacing reliion at me

How long it may take to cure the HIV completely. Any possibilities that we may cure it by end of 2010. Please revert

A total cure for HIV wont be readily available for several years. Testing and funding are things that take years to gain. However, HIV and AIDS are not the death sentences they used to be. Anti-retrovirals can bring the virus to a stand-still and even push it into hybernation-like state if caught early enough. People with AIDS can still live well into old age without major complications. A lot of it has to do with taking care of your body. Remember, HIV attacks the immune system. KEEP YOUR BODY HEALTHY! The human body is truly amazing, take care of it and even without anti-retrovirals you can live a long and happy life with the virus in you. Trust me, I've had the virus for 8 years and my doctor says my blood and immune system look healthier than his. If I can live through this, so can you.

god bless u. hope u live longer.
i want to know more about u.....like how u got hiv.and
have u ever taken arvs,and what was the side effects on u.and what social stigma did u face?
keep in touch

yes anil well said my friend
assad i lived with hiv for 10 years with out meds and lived a full positive life.i was a tv actor.the last 8 yrs((im hiv 18yrs)i have osteporosis becuase of the meds.also i have had lipodystropy for the the last 7yrs which has changes my appearance dramaticaly and my quality to my life has declind to the point of where i am a shadow to my self.dont preach to people my friend.i wish you good health but think before you speak and where your words land.love and light to you damien

I pray this cure is developed soon the world needs it. Even more, the world needs to have faith in the true healer GOD! He has the power to change anything. I believe!

well this looks very promising, im sure most of the researchers are true in their efforts but funding is the major issue, with todays technology and what we know today if there was funding im sure a cure or even a way to make the virus permanently dormant would be possible, but we should keep in mind that big pharmacuticals will do anything they can to hide this as they make millions from selling arvs. its sad how human nature is and how leaders of the world cannot do much on such important issues but never loose hope

Research is fine for the cure, what about vaccine first which can prevent from happening , ie hiv virus needs a host cell to make a copy, why can't they develop a vaccine to prevent this.
Lets hope there will be cure in year or 2.

people lets pray harder & hav a believe that they will get a cure.

Lets hope there is cure in the nearer future... Not nice wondering when my times is up. I get scared when i have 1 sip of beer or miss a meal.
Trying to be healthy is HARD work.

Doctors i have spoken to have said that the cure is long long away... I argued that if the ARVs suppress the virus then why couldn't they killed it?? They said its because there's hidden virus in the brain or that the ARVs is not strong enough to reach all place...

I pray every day and check online now and again in the hope that the headline would say "CURE BREAKTHROUGH" only to find that they have discovered how they work but nowhere near cure if not that close... But i am very hopeful that there will be cure... but its just the WHEN is what bugs me... I hope its just round the corner... Why can't all the sciencist in the world who work on it to work together! who cares about who found this method or that method first.. money is not important when we have our health to worry about and the future generation.. if there is no cure soon it will be disaster for our future generation. I got it through snorting coke (sharing straw) not realising you can catch it through that although the risks is very small.. but if i didn't know this then surely there's more ways to catch it that people wouldn't even know... what does that say...
Congrat to those devote science people who still work on it.. Lets do our bit by involving charities and rise money for the researchers and sciencists so that they can continue with the work.

I don't think we'll see a cure anytime soon. Pharmaceutical companies make too much money keeping HIV patients on their toxic drugs. Once in a while their research team make the headlines with a pseudo discovery that will bring hope of a cure and bring more funds for research. They just care about money...

i believe it, and i will be one of those researchers one day in the future!!!

There were more discoveries done in this year then in seceral past years, so lets hope it will happen really quick. But we all can speed it up! Yes! Join World Community Grid, which is using free computer cycles finding the cure. See: www.worldcommunitygrid.org

I hope there is cure in Ghana a man Dr Akuamoah Boateng who is a doctor have joined heads with some scientist in the US to find a herbal cure but people don't believe it,the herbal medicine is called mab formula 1 and mab formula 2 which kills the virus completely and boots up the immune system in advance.

I just cant immagine how long must all this sufferings go on or how many more poeple would have to? must die before "the cure" is discovered. Only hope and fate can sustain & take the millions of SICK persons there.

please find cure for HIV, I'm a very healthy sportive guy, haven't been to hospital in the past 10 years but recently they found HIV on my blood I'm so sad never felt that depth of saddness in my enitire life, just praying for you guys to find us cure, please please

d'nt feel bad every thing will be all right.keep u r mental ability in high standarad. hope we will get the medicine soon.pray for the god who gives us the medicine through scientists.

Hi we thank all people, consultant, Doctors who are involved in find the hiv-aids cure. The problems is that all drugs have side effect especiall the lipodostropy. We just now need God's intervetion to completely take control and remove this curse from us. The drugs are just to keep us on and on as they damage the system. God lord the creator of heaven, you promised that you never change, for give us our sins and heal this illness which has defited the dr. amen

I'm 17 year old, and a person infected me with this.. i dont think i can handle this.. i have my whole life ahead me but how can i live if i know i can never have a family, or my own child. Why this world must be hard and what did i do to deserve this

Do not be desparate. Of course its * to find out you are infected with HIV, but life does not end at that same moment. Hold your self together and make sure you are there when the cure gets to us. ITS POSSIBLE. All we have to do is take responsability and take care of our self. I am hopefull that the cure is close.

i'm sure God will heal you one day,for now keep praying for a cure.

There once was a leader in South Africa who was insulted and subsequently removed from parliament for fighting the pharmaceutical companies.
His name was Mr Thabo Mbeki.
In Africa these toxic treatment ARVs are being consumed on empty stomachs.

What happend to the TETRASIL Aids cure?

i have found some peace seeking out god, through him i have found some joy

I'm also 17 years old and infected. The truth is you can have a family, and you can find love. You're not going to die tomorow unexpectedly. It's not really a big deal, you use a condom and thats it. You have 30 years in front of you. Who knows how many people get hit by a car every day!

Bad things happen all the time, but that's life. Life isn't pristine health till you're old and suddenly something comes up. Stay optimistic, life goes on.

its easy to encourage but difficult to survive.... i think i am also infected (Not yet checked)
the first thing came to my mind is suicide.... y to leave with out family, love and respect..

Dear Depressed. You are very young still and have your whole life ahead of you still. I am positive and have had two babies and married to a wonderful man. You too can still have babies. You must remember mind, body, and soul. You cannot let your mind take you over with fear. Stay healthy and learn as much as you can about the virus. As well as what makes your body strong. I will be praying for you. I will be praying for us all stay strong.

hey, guys im + but my child is negative, um so happy thats my child will lead my dreams but um still looking afdter myself

hope when they find a cure it becomes available to everyone and doesn't get swept under the carpet in order for the pharmacutical companies to continue making billions, as for the seventeen year old, keep it together and be strong you can have your own family if you are a female it very easy and there is medication to prevent your unborn child from being born positive and if you are a male there is sperm washing so you won't infect your partner. For your sake and the millions of persons in the same situation like you i hope the get a cure ASAP

when is the cure coming out please do sothing people are diening everyday and people are not happy wt there self

Come on guys and girls, I am very sure that the cure is found ! But the problem is that all the professionals, hospitals, pharmaceutical companies, nurses, charities, etc.. etc.. DONT WANT TO LOOSE THEIR PROFITABLE LIVING and simply set free more than 33 millions of HIV carriers that depend on their services to live, JUST THINK !!!!!!

Keep up the continued support to find a cure and rid the world of this epidemic.

Thank you so much for all your dedication on research, this gives us hope to getting a cure. It will be the greatest news ever all world over.We can now start to imagine a generation free from HIV/AIDS.Though there's ARVs to prolong life for those with hiv, its really a drug burden to take medication everyday for life. We urgently need a cure. just imagine the kids born with the virus, its really miserable to see them take medication day in day out.even with the ARVs, these children dont live an absolutely free and happy lives.Doctors, researchers, physicians etc, please work so hard around the clock, a cure is urgently needed.

thank you all for the positive messages, us with the virus sometimes completely loose hope even with ARVs because of the stigima and toxicity of the drugs.Docs say they damage the liver, kidneys after a long time of use.WE NEED A CURE PLEASE.

the day there will be a cure to this hiv problem everyone in world will be very happy beleive it or not a cure will come b4 2015 praise GOD

I am 23 and HIV I admire you guys living with the virus for so many years and still having faith and hope. I on the other hand feel like I died already. I think about my death every singel day and I am longin for it. If there is a God out there, he has forgotten about me.

you will survive and get to be amongst the first who are cured. There are reasons HIV is important. Science is finding this virus to be like the Space Program. It is leading to deep and far-reaching understanding of disease, genetics and a lot more. They have a functional cure already which takes your own cells out and alters them genetically and replaces them later in a few months. That is only one way. The new mosaic vaccine, funded by Gates, is using a computer to generate more mutations than the virus can make, and programs it into the vaccine. This goes into human testing in 2012. It already shows a VERY strong immune response in animals. A third way is a new particle that infects the HIV virus itself. It cannot attach to anything else, so is harmless. It destroys the genes in the HIV, so that when the HIV multiplies it does not make more HIV, but more of these PARTICLES, which infect more of the HIV. All 3 of these methods will work, but the vaccine is the easiest/cheapest. You have good reason to expect to be cured, and this is real. Don't go into denial and take risks, or abandon your meds. Do what you can to clean up the body from the med-toxins..but for now the meds are what keeps you going, nothing else will. Drinking water, exercising, eat well as you can afford. And there will come a day when it is realized that everyone with HIV is in fact a hero, or heroine!

bG, can you provide a link or more information this the "new particle that infects the HIV". If this is to serve as a cure, I am very hopeful. The science behind this seems sound. However, i cannot find any information on this. As long as there is something to hold on to, i have hope, without information like this, life seems rather empty. I feel as though i can now experience a modicum of happiness as long as this information is true. I cannot handle having my hopes crushed. I will not survive it.

is it complete cure possible ?

hello everybody i m guy 31 years old ,recently i kew i m also infected from hiv , now a days i m going through preasure for marring anyone by my famliy what can i do i did't understand , and is it not possible to find the girl match me.i have reputed job income n other things too

plz make it soon JESUS bless u all

yes a cure will happen, here is why,, one of the fastest growing population getting hiv/aids is women so im told, they are the mothers of life, and the screaming has started, not even the parm co. can turn a deaf ear, this is the modern day plauge, give your prayers and also what you can afford, nothing gets done without money..

it is a really good news//

Hello ,
My comment is to pray for the Dr's who are doing the reseach all over , cause am one persone living with Hiv and hoping that day will come soon ,keep it up.

My opinion on HIV is basic; To cure HIV find the source. I think I know the source and it is not from monkeys because if it was the question still stands, where did the monkeys get the SIV from? I need experts to contact me on this issue. I have been doing research in my private capacity for 17 years. E-mail jabulanijoe@gmail.com.

I appreciate and thankful for dr.s and scientists. My GOD bless them all. May GOD bless us all. I hope for cure soon. Im also innfected and hope that GOD can forgive us and give us strength. PLEASE GOD LET THEM FIND A CURE SOON.

this is a good news may god give all your team divine wisdom in jesus name amen

i pray that this works out cz i have hope that before the end of the decade people like me will be well.

today is my worest day ever i went check up but i found out i am hiv positive ,i cant crying the whole day and night i am praying the dr. find the cure please my lord jess help us.

can u give me the changes of cure of a person whose CD4 is 74

Hi there, I just want to first say stress will be your biggest enemy. I have talked to several people who found out when their CD4 was at 50 and below... now they are on meds and up past the 300's and one i know is at 1100 already. its terrifying at first, i know, i am recently diagnosed... but your best bet is to talk to people who are doing awesome. i go on hivnet.com to the chat room and talk to people and they are great at support. Youll be fine. the only thing i can say is listen to your dr's. dont skimp and just go to whoever... go to the best you can find. also, most of my drs believe that their will be a cure in 10 years but no matter what we will always test positive for the virus. its no different than mono, chicken pox, measles etc... if you were to take those tests you will still test positive because the antibodies are still present in your system. also, its great that you believe in god, but HE will not cure you. you need to be dependent on your medical team and follow their instructions. that being said... take care and dont worry about it... youll be fine

Is there any more news on this? It's been a long time since the article. Has anyone noticed how a new AIDS/HIV breakthrough seems to come out every so often and then we hear nothing more about it... its as if it's all hype? For example, is the treatment available at the doctor yet? Can we see a schedule of planned testing phases, and get updates etc.? Its as if they report it and it always vanishes into the ether.

wil be there any 100% cure for hiv positive curesoon?

This is very encouraging. We are very desperate for a cure. May God give the you victory!!!!!

WOW! This is better than best. Keep up we are waiting in anticipation for this long awaited cure. But please give me some of it to try and trial and test with myself

in zambia herbs are also on research but they is need to look at them very well in 2006 clinical trial were undertaken on 26 HIV postive people there only thing that showed is that herbs can prolonge life as well due to lack of funds the trails were onnly for 6 months but the results were very good to these who undertook the trails . it is very imporatat that all country come together and find and support each other in the research for the cure we vshould share our findings from the baseline look at the CD4 VRIOLAOD and other we are man and weman who can make a charge

plzzzzzzzzzzzzzz........ find the drug for curing hiv.we know our abilities but put them in a right way, hope we will get it for sure with in few days but plzzzz try for those who are living with hiv with commiting a mistake

what about the cure dictected by a doctor in ghana what about the natural cure dictected in indian and now on sales, why are this researchers not talking about it, who care who gets the cure, what is important is people to get well and cure pamanently not managing it thanks

VERY IMPRESSIVE DISCOVERY, KEEP IT UP AND SERVE THE HUMAN KIND.

thanx 4 the gud nuz. i feel when such gud nuz is around the corner, such reputable scientists/researchers shudnt let it jus go lyk that. they shud take pararell progressions of their experiments with some giving hourly results, daily results, weekly results, monthly, yearly and some 5 year results continuously and simulteneously. i believe with such force and proper funding best nuz is coming lyk tomorow. hey please assist the needy. thank u.

it is really good what you are doing, please go ahead and find new life for those who looks to you. also i suggest you to take advantage of cow urine as it found good to fight hiv virus.