The name says it all. Destroy all humans! 2 is a hilariously entertaining game which primarily evolves around "blowing things up", as the little green men put it, so why not do it proficiently? There are a lot of workarounds to do maximum damage and bring havoc to the streets without breaking a sweat so we might as well start with Coyote Bongwater.
At this point in the game, only two weapons should be available to you, the Zap-o-matic and the Disclocator. The problem is that none of these works effectively against the KGB agents and Bongwater, so you must get something extra. This is why you need to take a good look around before engaging him. At the very start of the level, towards the far left wall, there are large Revelade containers, surrounded by small barrels. They are explosive barrels to be more precise. Just as the level starts, quickly use the jetpack to fly towards the left side of the room and take cover behind the Revelade containers. While hidden,
use your PK ability on one of the explosive barrels to get it levitating. You have a choice now, to either swing it at the KGB agents and Bongwater, or press Triangle again to simply push it. Thus you don't have to use your weapons at all, since the explosion will do away with most agents. Bongwater himself will die in three explosions at the most. Naturally, pay attention to the explosion radius, since any miscalculation will get you hurt badly of even killed.
To defeat the KGB boss in Alibon, you must avoid his first attack. Just keep running and avoid his line of sight behind pillars and boxes. Once he's done attacking, take out your Anal Probe and shoot once. He should gradually return to normal, but just in case, shoot him again. When his transformation is complete, zap the green gas in the air and finish him off with your Disintegrator Ray. Mutants are even easier. Use the Anal Probe on the mutant and he'll turn human again. Kill the purple mist that comes out before it infects someone else, with any weapon except the probe. Humans don't need to be killed afterwards, but if you want to have some fun with them, there is one trick you can do. Take a person with the Abducto Beam, but release [L1] once you select "Store". They will slam into the saucer with a huge bang.
Otherwise, just store him the usual way. If you've had enough of Holobob being deactivated by Majestic, just steal people's bodies. To do it, you must use Free Love when people see you, so that you'll get away with it. When your alert level is high, just snatch the body of someone in charge. Use your newly found political power to call in the All Clear and your alert will go down. It's time to use the Gene Blender, so press [X] when you're getting inside the ship, or whenever the Abducto beam is not activated. You'll henceforth be snatching bodies faster, but at some point, you'll only be able to steal KGB agents for bodies.
A great way to travel is when you're playing the two-player mode. You and your friend should get dumpsters next to one another, and then jump on top. Each sound now uses PK to make the other person's dumpster levitate, so press [Up]. Simply direct the beams in the same direction and you have your own unseen vehicle ready for a bumpy ride. It's a great tool, once you master the synchronous moving patterns. If you want a good weapon, you can get the Quantum Deconstructor in Tunguska. Move to Tarkovescote and hold [O] once you get there. The weapon will now show on the mini-map. If you want extra kicks, just stay idle and the screen will switch colors to black and white, acting up like an old television show.
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