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Breast Cancer Connected to Alcohol Consumption

Even in moderated doses

By Stefan Anitei, Science Editor

30th of April 2007, 08:12 GMT

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It is said that one-two cups of wine daily means a better heart.

But a new research made at the University of Mississippi
Medical Center revealed that moderate alcohol intake, of just about two drinks daily, can induce breast cancer. Breast tumors that grew in mice which were offered a similar daily drink were twice larger than in mice that did not taste alcohol. This new research not only reveals the connection alcohol - breast cancer, but it also shows how alcohol stimulates tumor growth.

"Alcohol [consumption] is the most important avoidable risk factor for women getting breast cancer," said lead researcher Jian-Wei Gu, alluding to "unavoidable" genetic factors.

The team gave to six-week-old female mice moderate alcohol quantities for four weeks, an equivalent of two cups of wine daily for humans. After a week, the mice females were injected with breast-cancer cells into the mammary glands. The resulting tumors in the alcohol-fed individuals weighed on average roughly 1.4 grams, about twice than in mice that did not consume alcohol and the lump was clearly visible. The researchers put this difference on the blood vessels growth stimulation induced by alcohol.

Alcohol is a toxin and the cells overdrive to get rid of it: they emit chemicals, induce the growth of blood vessels, but the same vessels are exactly what a tumor needs to exist, as they provide oxygen and nutrients. The alcohol-fed mice indeed had increased levels of VEGF hormone (that stimulates blood vessels growth) and more blood vessels than the other mice.

"This is the first study to use an animal model that accurately mimics human breast cancer," said Gu.

Other researches investigated tumor formation in mice lacking an immune system, but that does not mimic real situations.

"In regular mice, if you implant a human tumor, it won't grow because it's foreign [so the immune system would stage an attack]," said study team member Emily Young.

These discoveries can be applied to humans and could prevent and help treating the breast cancer.

"Normal people produce cancer cells every day, but at the beginning the cancer doesn't have blood vessels." said Gu.

This eases the action of the body's immune system, but when helped by alcohol intake, the cancer cells can get a grip.

TAGS:

alcohol | cancer | breast


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User opinions:


Comment #1 by: minnie9598 on 16 Jun 2007, 05:17 GMT reply to this comment

yes, I feel that alcohol has contributed to my breast cancer. My cancer has recurred for the forth time.


Comment #2 by: minnie9598 on 16 Jun 2007, 05:19 GMT reply to this comment

I was never told there was a connection but I always felt that something was happing in my stomach when I drank. I had an uncomfortable feeling and a bloatedness. My breast cancer recurred in my abdomen wall last year. I was never told to stop drinking and was never a big drinker. I drank about one to two drinks about three times a week.


Comment #3 by: minnie9598 on 16 Jun 2007, 05:23 GMT reply to this comment

My breast cancer has now recurred for the fourth time in my liver. I have lesions ranging from 2cm to 5cm and am receiving chemo. I had previously been on Letrozole and Arimadex. These two drugs were prescribed in the past six months and both did not work one bit in stopping the cancer. They only gave me great pain. That is the side effects. Joint pains were terrible. I felt like I was walking on broken glass. I went up a shoe size due to swelling and could not wear rings due to swelling in my joints. The hot flushes were dreadful. They came very frequently and very strongly.

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