Mostly known for his roles in action movies such as Predator (1987) and Commando (1985), Bill Duke will be playing a politician in The President's Cabinet, according to IGN FilmForce. He has worked previously with the X-Men 3 director, Brett Ratner, on Red Dragon (2003).

Michael Murphy (Batman Returns (1992), Shocker (1989)) will take on the role of Angel's father, Warren Worthington Sr.

Olivia Williams (The Sixth Sense (1999)) will be playing Dr. Moira MacTaggert.

Also, many actors in the cast for the previous movies reunited for X-Men 3, including Hugh Jackman, Halle Berry, Rebecca Romijn, Ian McKellen, and Patrick Stewart.